Positive selection of natural autoreactive B cells.

  title={Positive selection of natural autoreactive B cells.},
  author={K. Hayakawa and M. Asano and S. Shinton and M. Gui and D. Allman and C. Stewart and J. Silver and R. R. Hardy},
  volume={285 5424},
  • K. Hayakawa, M. Asano, +5 authors R. R. Hardy
  • Published 1999
  • Biology, Medicine
  • Science
  • Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene-encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the… CONTINUE READING
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