Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors.

@article{Xiong2004PositiveSO,
  title={Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors.},
  author={Na Xiong and Chuhlo Kang and David H Raulet},
  journal={Immunity},
  year={2004},
  volume={21 1},
  pages={
          121-31
        }
}
The role of cellular selection in the development of gammadelta T cells remains unclear. Knockout mice lacking a subset of Vgamma genes, including Vgamma3, contain abundant gammadelta T cells but are devoid of dendritic epidermal gammadeltaT cells (DETCs), which normally express an invariant Vgamma3/Vdelta1 gammadelta TCR. A rearranged Vgamma2 transgene restored DETC development, but the restored DETCs selectively expressed a unique Vdelta gene other than Vdelta1, indicating that DETC… CONTINUE READING

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