Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

Abstract

T LYMPHOCYTES recognize antigens as peptide fragments associated with molecules encoded by the major histocompatibility complex (MHC) and expressed on the surface of antigen-presenting cells1. In the thymus, T cells bearingαβ receptors that react with the MHC molecules expressed by radioresistant stromal elements are positively selected for maturation2–5… (More)
DOI: 10.1038/359729a0

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