Positive response to imatinib mesylate therapy for childhood chronic myeloid leukemia.


Chronic myeloid leukemia (CML) is rare in the pediatric population, accounting for 2-3% of childhood leukemia cases, with an annual incidence of one case per million children. The low toxicity profile of imatinib mesylate has led to its approval as a front-line therapy in children for whom interferon treatment has failed or who have relapsed after allogeneic transplantation. We describe the positive responses of 2 children (case 1 - from a 7-year-old male since May 2005; case 2 - from a 5-year-old female since June 2006) with Philadelphia-positive chromosome CML treated with imatinib (300 mg/day, orally) for up to 28 months, as evaluated by morphological, cytogenetic, and molecular approaches. Our patients are alive, are in the chronic phase, and are in continuous morphological complete remission.

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@article{Oliveira2010PositiveRT, title={Positive response to imatinib mesylate therapy for childhood chronic myeloid leukemia.}, author={G A P Oliveira and Elaine S. Costa and Maria Silvia Freitas and Fabiano Ferreira Dutra and Simone F. Maia and Marcelo C Guerra and Mar{\'i}a Dolores Tabernero and Rajka Borojevic and Ivone Beatriz Otazu and Jarques L{\'u}cio Silva}, journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas}, year={2010}, volume={43 6}, pages={580-4} }