Positive reinforcing effects of flupirtine — Two case reports

  title={Positive reinforcing effects of flupirtine — Two case reports},
  author={Christina Stoessel and Annemarie Heberlein and Thomas Hillemacher and Stefan Bleich and Johannes Kornhuber},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease
It is proposed that to optimally alleviate this motor complication of Parkinson’s disease, it may be necessary to develop combined treatment approaches that will target simultaneously more than one neurotransmitter system.
Pharmacology and clinical applications of flupirtine: Current and future options
  • K. Lawson
  • Biology, Medicine
    World Journal of Pharmacology
  • 2019
Flupirtine is providing important information and clues regarding novel mechanistic approaches to the treatment of a range of clinical conditions involving hyper-excitability of cells, and identification of molecules exhibiting specificity for the pharmacological targets involved in the actions of fl upirtine will provide further insight into clinical applications.
Flupirtine dependence and withdrawal syndrome
In the case reported here, flupirtine withdrawal was monitored by psychometric scales over the inpatient treatment including Beck Depression Inventory (BDI) and specific withdrawal scales for benzodiazepine withdrawal such as the Clinical Institute Withdrawal Assessment scale-Benzodiazepines (CIWA-B) and the BenzodiazepINE Craving Questionnaire (BCQ).
Gamma Glutamyl Transferase Activity ( Ggt ) In Albino Rats Treated With Orphenadol Analgesics 1
The findings of this research indicate that the toxic effects or the adverse effect of orphenadol may include the hepatobiliary system and total protein concentration were found to be dose-dependent.
Abuse liability of flupirtine revisited: Implications of spontaneous reports of adverse drug reactions
The hypothesis that FLP features a potential to cause addictive behaviors is strengthened, as female sex, age >40 years, and long‐term FLP‐treatment may be possible risk factors for the development of FLP abuse/dependence.
Dependence on Flupirtine


Neural KCNQ (Kv7) channels
KCNQ genes encode five Kv7 K+ channel subunits, which are the principal molecular components of the slow voltage‐gated M‐channel, which widely regulates neuronal excitability, although other subunits may contribute to M‐like currents in some locations.
Ion channels as potential targets for the treatment of depression.
  • N. Lodge, Yu-Wen Li
  • Biology, Psychology
    Current opinion in drug discovery & development
  • 2008
Major depressive disorder is highly prevalent and remains inadequately treated. Numerous studies have demonstrated that modulation of ion channel activity can reduce depression-like behavior in
Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients.
Data support further exploration of whether well-tolerated NMDA receptor antagonists might have a role in the treatment of alcoholism and suggest memantine attenuated alcohol cue-induced craving in a dose-related fashion.
Mutation screen of the GAD2 gene and association study of alcoholism in three populations
  • J. Lappalainen, E. Krupitsky, J. Gelernter
  • Biology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2007
It is suggested that variation in GAD2 is not a major risk factor for AD in EAs and its role may be limited to susceptibility to severe AD.
Changes in the biogenic amine content of the prefrontal cortex, amygdala, dorsal hippocampus, and nucleus accumbens of rats submitted to single and repeated sessions of the elevated plus-maze test.
It is suggested that exposure to the EPM causes reduced monoaminergic neurotransmission activity in limbic structures, which appears to underlie the "one-trial tolerance" phenomenon.
Acute effects of memantine in combination with alcohol in moderate drinkers
RationaleAlcohol effects in humans involve N-methyl-d-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission. It has been proposed that NMDA receptor antagonists may be effective in the
The therapeutic potential of neuronal KCNQ channel modulators
  • V. Gribkoff
  • Biology, Psychology
    Expert opinion on therapeutic targets
  • 2003
Data have suggested a rich target profile for modulators of neuronal KCNQ channels, including a variety of neuronal hyperexcitability disorders and conditions for openers, such as the epilepsies, acute pain, neuropathic pain, migraine pain and some neurodegenerative and psychiatric disorders.
Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels
A global model was developed in which flupirtine stabilizes the resting membrane potential by activating inwardly rectifying K+ channels, thus indirectly inhibiting the activation of NMDA receptors.
Dose-related analgesic effects of flupirtine.
The present investigation was conducted in order to investigate dose-related effects of perorally administered flupirtine in man, with special regard to specifically analgesic actions, employing a model based on pain-related chemosomatosensory evoked potentials and subjective intensity estimates of painful stimuli.