Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells.

@article{George1999PositiveRO,
  title={Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells.},
  author={Thaddeus C. George and L. H. Mason and John R. Ortaldo and Vinay Kumar and Michael Bennett},
  journal={Journal of immunology},
  year={1999},
  volume={162 4},
  pages={2035-43}
}
Members of the murine Ly49 family of receptors have been shown to inhibit and activate NK cell function. Subsets of Ly49-expressing NK cells mediate the rejection of bone marrow cell allografts and the lysis of allogeneic lymphoblasts. In this report we have studied Ly49-mediated positive and negative signaling in an in vitro cytotoxicity assay using sorted NK cell subsets as effectors and a panel of 51Cr-labeled Con A lymphoblasts as targets in the presence or the absence of Abs to Ly49 and/or… CONTINUE READING
68 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Similar Papers

Loading similar papers…