Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.

@article{Paterson2008PositiveMO,
  title={Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.},
  author={Neil E. Paterson and Styliani Vlachou and S{\'e}bastien Guery and Klemens Kaupmann and Wolfgang Froestl and A. Markou},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={326 1},
  pages={306-14}
}
Acute administration of gamma-aminobutyric acid (GABA)-B receptor agonists decreases nicotine, cocaine, ethanol, and heroin self-administration and also decreases food-maintained responding and suppresses locomotor activity at high doses. GABA(B) receptor-positive modulators may represent potentially improved therapeutic compounds because of their fewer side effects than receptor agonists. The present study investigated the effects of administration of the GABA(B) receptor-positive modulators 2… CONTINUE READING
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Multiple motivational forces underlying nicotine dependence, in The Motivational Impact of Nicotine and Its Role in Tobacco Use (series title

  • A Markou, NE Paterson
  • Nebraska Symposium Motivation
  • 2008
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