Positive inotropic effects of hydralazine in human subjects: comparison with prazosin in the setting of congestive heart failure.

@article{Leier1980PositiveIE,
  title={Positive inotropic effects of hydralazine in human subjects: comparison with prazosin in the setting of congestive heart failure.},
  author={Carl V. Leier and Christopher E. Desch and R D Magorien and D W Triffon and Donald V. Unverferth and Harisios Boudoulas and Richard L. Lewis},
  journal={The American journal of cardiology},
  year={1980},
  volume={46 6},
  pages={1039-44}
}
Hydralazine possesses positive inotropic properties in animal model preparations. To determine whether this vasodilator elicits a positive inotropic response in the failing human ventricle, hydralazine, 75 or 100 mg, was administered orally to 14 patients with left ventricular dysfunction and congestive heart failure; the results were compared with those of first-dose prazosin at 5 and 10 mg. The duration of the preejection period and the isovolumic developed pressure/duration of isovolumic… CONTINUE READING