Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.

@article{Nasa1992PositiveIA,
  title={Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.},
  author={Yoshihisa Nasa and Kazuo Ichihara and Ryo Yoshida and Yasushi Abiko},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 3},
  pages={
          696-702
        }
}
1. The cardiovascular effects of (-)-cis-diltiazem, an optical isomer of diltiazem, were studied in the isolated atrium and aortic strip. (-)-cis-Diltiazem (30 microM or more) increased the developed tension of the rat left atrium, while (+)-cis-diltiazem (1 microM or more) decreased it. 2. (-)-cis-Diltiazem (1 to 100 microM) decreased the rate of spontaneous beating in the right atrium as did (+)-cis-diltiazem. 3. The potency of the positive inotropic action of (-)-cis-diltiazem was almost the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone.

  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2004
VIEW 2 EXCERPTS
CITES BACKGROUND