Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.

@article{Mao2013PositiveFR,
  title={Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor.},
  author={Xu-ming Mao and Zhi-hao Sun and Bi-Rong Liang and Zhi-bin Wang and Wei-hong Feng and Fang-Liang Huang and Yong-Quan Li},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 9},
  pages={2072-8}
}
LysR-type transcriptional regulators (LTTRs) compose a large family and are responsible for various physiological functions in bacteria, while little is understood about their regulatory mechanism on secondary metabolism in Streptomyces. Here we reported that StgR, a typical LTTR in Streptomyces coelicolor, was a negative regulator of undecylprodigiosin (Red) and γ-actinorhodin (Act) production in the early developmental phase of secondary metabolism by suppressing the expression of two pathway… CONTINUE READING