Positive feedback interactions between microtubule and actin dynamics during cell motility.

  title={Positive feedback interactions between microtubule and actin dynamics during cell motility.},
  author={Clare M. Waterman-Storer and E P Salmon},
  journal={Current opinion in cell biology},
  volume={11 1},
The migration of tissue cells requires interplay between the microtubule and actin cytoskeletal systems. Recent reports suggest that interactions of microtubules with actin dynamics creates a polarization of microtubule assembly behavior in cells, such that microtubule growth occurs at the leading edge and microtubule shortening occurs at the cell body and rear. Microtubule growth and shortening may activate Rac1 and RhoA signaling, respectively, to control actin dynamics. Thus, an actin… CONTINUE READING

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