Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus.

@article{Knipper1994PositiveFB,
  title={Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus.},
  author={M. Knipper and M da Penha Berzaghi and Andrea Bl{\"o}chl and Heinz Breer and Hans Thoenen and Dan Lindholm},
  journal={The European journal of neuroscience},
  year={1994},
  volume={6 4},
  pages={668-71}
}
In the rat hippocampus, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are synthesized by neurons in an activity-dependent manner. Glutamate receptor activation increases whereas GABAergic stimulation decreases NGF and BDNF mRNA levels. Here we demonstrate that NGF and BDNF mRNA and NGF protein are up-regulated in the rat hippocampus by the activation of muscarinic receptors. Conversely, NGF and BDNF enhance the release of acetylcholine (ACh) from rat hippocampal… CONTINUE READING