Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.

@article{Kagoya2014PositiveFB,
  title={Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.},
  author={Yuki Kagoya and Akihide Yoshimi and Keisuke Kataoka and Masahiro Marshall Nakagawa and Keiki Kumano and Shunya Arai and Hiroshi Kobayashi and Taku Saito and Yoichiro Iwakura and Mineo Kurokawa},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 2},
  pages={
          528-42
        }
}
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy that originates from leukemia-initiating cells (LICs). The identification of common mechanisms underlying LIC development will be important in establishing broadly effective therapeutics for AML. Constitutive NF-κB pathway activation has been reported in different types of AML; however, the mechanism of NF-κB activation and its importance in leukemia progression are poorly understood. Here, we analyzed myeloid leukemia mouse… CONTINUE READING

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