Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.

@article{Alonso2006PositiveEO,
  title={Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.},
  author={Ana Alonso and Rebeca Fern{\'a}ndez and Mar{\'i}a Moreno and P. Mart{\'i}n Ord{\'o}{\~n}ez and H{\'e}ctor Gonz{\'a}lez-Pardo and N{\'e}lida M. Conejo and Fernando D{\'i}az and Celestino Gonz{\'a}lez},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2006},
  volume={61 5},
  pages={419-26}
}
Aging is associated with insulin resistance, which represents a common factor in age-related diseases. We aimed to determine the role of 17beta-estradiol on insulin sensitivity and memory during aging using ovariectomized rats (2-26 months of age) treated with physiological doses of 17beta-estradiol. Our results indicate a lack of effect of 17beta-estradiol replacement on spatial memory assessed in a water maze. Conversely, estradiol treatment improved insulin sensitivity in aging rats. These… CONTINUE READING

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  • I Harukuni, PD Hurn, BJ Crain
  • 2005

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