Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.

@article{Frasor2009PositiveCB,
  title={Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer.},
  author={Jonna M. Frasor and Aisha E Weaver and Madhumita Pradhan and Yang Dai and Lance D. Miller and Chin-Yo Lin and Adina Stanculescu},
  journal={Cancer research},
  year={2009},
  volume={69 23},
  pages={8918-25}
}
Estrogen receptors (ER) and nuclear factor-kappaB (NF-kappaB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-kappaB can also act together in a positive manner to synergistically increase gene transcription. To examine the extent of cross-talk between ER and NF-kappaB, a microarray study was conducted in which MCF-7 breast cancer cells were treated with 17beta-estradiol… CONTINUE READING
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