Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress.

@article{Oliveira2011PositiveCB,
  title={Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress.},
  author={J C Alexandre de Oliveira and Mariana Appel Hort and Eduardo Luiz Gasnhar Moreira and Viviane Glaser and R M Ribeiro-do-valle and Rui Daniel Prediger and Marcelo Farina and Alexandra Latini and Andreza Fabro de Bem},
  journal={Neuroscience},
  year={2011},
  volume={197},
  pages={99-106}
}
Convergent epidemiological, clinical, and experimental findings indicate that hypercholesterolemia contributes to the onset of Alzheimer's disease (AD)-like dementia, but the exact underlying mechanisms remains unknown. In this study, we evaluated the cognitive performance of mice submitted to a model of hypercholesterolemia, as well as its relationship with mitochondrial dysfunction and oxidative stress, two key events involved in AD pathogenesis. Wild-type C57bl/6 or low density lipoprotein… CONTINUE READING

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