Positive control of tylosin biosynthesis: pivotal role of TylR.

  title={Positive control of tylosin biosynthesis: pivotal role of TylR.},
  author={George Stratigopoulos and Neil Bate and Eric Cundliffe},
  journal={Molecular microbiology},
  volume={54 5},
Control of tylosin production in Streptomyces fradiae features interplay between a repressor, TylQ, and an activator, TylS, during regulation of tylR. The latter encodes a pathway-specific activator that controls most of the tylosin-biosynthetic (tyl) genes that are subject to regulation. This was established by targeted gene disruption applied separately to tylR and tylS together with transcript analysis involving reverse transcription polymerase chain reaction (RT-PCR). TylR controls multiple… CONTINUE READING
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