Positive chronotropic and inotropic effects of angiotensin II in the dog heart.

@article{Kobayashi1978PositiveCA,
  title={Positive chronotropic and inotropic effects of angiotensin II in the dog heart.},
  author={Motomasa Kobayashi and Yasuyuki Furukawa and Shigetoshi Chiba},
  journal={European journal of pharmacology},
  year={1978},
  volume={50 1},
  pages={17-25}
}
The effects of angiotensin II on sinus rate and atrial contractility were investigated in 17 isolated canine atria and 5 isolated paced ventricular preparations perfused with arterial blood conducted from a heparinized donor dog. When angiotensin II was injected into the cannulated sinus node artery, positive chronotropic responses were dose-dependently produced starting from the 0.01 microgram dose although inotropic responses to angiotensin II were not consistently induced. Angiotensin II… CONTINUE READING

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