Positive benefits of theophylline in a randomized, double‐blind, parallel‐group, placebo‐controlled study of low‐dose, slow‐release theophylline in the treatment of COPD for 1 year

@article{Zhou2006PositiveBO,
  title={Positive benefits of theophylline in a randomized, double‐blind, parallel‐group, placebo‐controlled study of low‐dose, slow‐release theophylline in the treatment of COPD for 1 year},
  author={Yumin Zhou and Xiao-ping Wang and Xiangyi Zeng and Rong Qiu and Jun-fen Xie and Sheng-ming Liu and Jingping Zheng and Nanshan Zhong and Pixin Ran},
  journal={Respirology},
  year={2006},
  volume={11}
}
Objective and background:  Increasing evidence suggests that low‐dose theophylline has anti‐inflammatory benefits and is safe in the treatment of COPD. This study aims to evaluate the efficacy and safety of low‐dose, slow‐release oral theophylline administered over a 1‐year period in patients with COPD. 
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TLDR
This large, rigorously conducted RCT showed that the combination of low-dose theophylline and prednisone did not affect exacerbation rate in patients with moderate to severe COPD in China.
Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD.
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Combination therapy with an inhaled corticosteroid and low-dose theophylline may attenuate airway inflammation in patients with COPD.
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Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial
TLDR
Among adults with COPD at high risk of exacerbation treated with inhaled corticosteroids, the addition of low-dose theophylline, compared with placebo, did not reduce the number of COPD exacerbations over a 1-year period.
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YuPingFeng granules can be considered as a treatment option for COPD; this treatment prevents acute exacerbations of COPD and has a good safety profile.
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TLDR
SFC therapy achieved sustained improvement in lung function, quality of life, and control of symptoms, and was well tolerated in Chinese patients.
Benefits of high-dose N-acetylcysteine to exacerbation-prone patients with COPD.
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High-dose NAC (600 mg bid) for 1 year reduces exacerbations and prolongs time to first exacerbation in high-risk but not in low-risk Chinese patients with COPD.
Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT.
TLDR
Low-dose theophylline was added to a drug regimen containing ICSs in people with COPD at high risk of exacerbation to determine the clinical effectiveness and cost-effectiveness and the limitation of not using documented exacerbations is addressed.
A rational approach to single, dual and triple therapy in COPD
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Following a review of how currently available treatments perform in isolation and when compared with each other, an approach to aid the rational selection of the most appropriate treatment based on current evidence is suggested.
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