Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia.

@article{Fujii2003PositiveAO,
  title={Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia.},
  author={Yo Fujii and Hiroki Shibata and Rumiko Kikuta and Chieko Makino and Ayako Tani and Naotsugu Hirata and Atsushi Shibata and Hideaki Ninomiya and Nobutada Tashiro and Yasuyuki Fukumaki},
  journal={Psychiatric genetics},
  year={2003},
  volume={13 2},
  pages={71-6}
}
OBJECTIVES Glutamatergic dysfunction is one of the major hypotheses of schizophrenia pathophysiology. We have been conducting systematic studies on the association between glutamate receptors and schizophrenia. We focused on the metabotropic glutamate receptor type 3 gene (GRM3) as a candidate for schizophrenia susceptibility. METHODS We genotyped Japanese schizophrenics (n=100) and controls (n=100) for six single nucleotide polymorphisms (SNPs) located in the GRM3 region at intervals of… CONTINUE READING

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