Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia.

Abstract

Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosomes 13.

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@article{Inayama1996PositiveAB, title={Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia.}, author={Yoshiyaki Inayama and Hiroshi Yoneda and Tsutomu Sakai and Toshihiko Ishida and Yasuhiro Nonomura and Yoko Kono and Risa Takahata and Jamie G Koh and Jo Sakai and Atsushi Takai and Yuji Inada and Hiroyuki Asaba}, journal={American journal of medical genetics}, year={1996}, volume={67 1}, pages={103-5} }