Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.

  title={Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.},
  author={Wenbin Xiao and Hajime Nishimoto and Hong Hong and Jiro Kitaura and Satoshi Nunomura and Mari Maeda-Yamamoto and Yuko Kawakami and Clifford A Lowell and Chisei Ra and Toshiaki Kawakami},
  journal={Journal of immunology},
  volume={175 10},
Aggregation of the high affinity receptor for IgE (FcepsilonRI) induces activation of mast cells. In this study we show that upon low intensity stimulation of FcepsilonRI with monomeric IgE, IgE plus anti-IgE, or IgE plus low Ag, Lyn (a Src family kinase) positively regulates degranulation, cytokine production, and survival, whereas Lyn works as a negative regulator of high intensity stimulation with IgE plus high Ag. Low intensity stimulation suppressed Lyn kinase activity and its association… CONTINUE READING


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