Positive and negative regulation of granulopoiesis by endogenous RARalpha.

  title={Positive and negative regulation of granulopoiesis by endogenous RARalpha.},
  author={PH. KASTNER and Hugh Jeffrey Lawrence and Caroline Waltzinger and Norbert B. Ghyselinck and Pierre Chambon and Susan Chan},
  volume={97 5},
Acute promyelocytic leukemia (APL) is always associated with chromosomal translocations that disrupt the retinoic acid receptor alpha (RARalpha) gene. Whether these translocations relate to a role for endogenous RARalpha in normal granulopoiesis remains uncertain because most studies addressing this question have used non-physiological overexpression systems. Granulocyte differentiation in cells derived from RARalpha-deficient (RARalpha(-/-)) mice was studied and evaluated in the context of… CONTINUE READING


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