Positive Selection on MMP3 Regulation Has Shaped Heart Disease Risk

@article{Rockman2004PositiveSO,
  title={Positive Selection on MMP3 Regulation Has Shaped Heart Disease Risk},
  author={Matthew V Rockman and Matthew W. Hahn and Nicole Soranzo and Dagan A. Loisel and David K. Goldstein and Gregory A. Wray},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1531-1539}
}
BACKGROUND The evolutionary forces of mutation, natural selection, and genetic drift shape the pattern of phenotypic variation in nature, but the roles of these forces in defining the distributions of particular traits have been hard to disentangle. To better understand the mechanisms contributing to common variation in humans, we investigated the evolutionary history of a functional polymorphism in the upstream regulatory region of the MMP3 gene. This single base pair insertion/deletion… CONTINUE READING