Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents

@inproceedings{Sakar2009PositiveRC,
  title={Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents},
  author={Yassine Sakar and Corinne Nazaret and Philippe Lett{\'e}ron and Amal Ait Omar and Mathilde Avenati and Benoit Viollet and Robert A Ducroc and Andr{\'e} Bado},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND AND AIMS The small intestine is the major site of absorption of dietary sugars. The rate at which they enter and exit the intestine has a major effect on blood glucose homeostasis. In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences. METHODOLOGY Wistar rats, wild type and AMPKalpha(2) (-/-) mice were used. In vitro and in vivo isolated jejunal loops… CONTINUE READING