Positive Feedback of Vasopressin on its Own Release in the Central Nervous System: in vitro Studies

@article{Ramirez1990PositiveFO,
  title={Positive Feedback of Vasopressin on its Own Release in the Central Nervous System: in vitro Studies},
  author={Victor Domingo Ramirez and Archimedes Ramirez and Flor{\'e}al Rodriguez and Jean-didier Vincent},
  journal={Journal of Neuroendocrinology},
  year={1990},
  volume={2}
}
In this paper evidence is shown that synthetic arginine vasopressin (AVP) can evoke marked in vitro release of endogenous immunoreactive AVP (I‐AVP) from male rat septal and hypothalamic tissue superfused in vitro. The stimulatory action was dosedependent with a maximal amplification factor of 2.3 when using 14 pg of synthetic AVP as the stimulus. It was highly specific since only AVP was effective and not three closely related substances such as lysine vasopressin, oxytocin and a 4–9 C… 
Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies.
  • M. Ludwig
  • Biology
    The American journal of physiology
  • 1995
TLDR
It has been demonstrated that administration of exogenous OT causes local peptide release and that, in vivo, this facilitates the milk ejection reflex, leading to the idea that endogenous peptides are released into the hypothalamic nuclei.
Osmotic stimulation of the supraoptic nucleus: central and peripheral vasopressin release and blood pressure.
TLDR
Simultaneous brain and blood microdialysis showed that hyperosmotic NaCl increased central and peripheral AVP release and increased mean arterial pressure (MAP) while the peripheral effects on AVPrelease and MAP are specific for sodium.
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TLDR
The findings demonstrate a significant activation of the septal vasopressinergic system in response to swim stress and support the view that AVP released within this brain area is involved in the generation of active behavioural strategies aimed at coping with new and challenging situations.
Effects of central vasopressin administration to infant rats.
Stress, Corticotropin and Central Effects of Adrenal Steroids
TLDR
Results suggest that intracerebroventricular leptin administration activates the HPA axis by AVP receptor activation through V1a receptors in the PVN which in turn activates CRH neurons to drive ACTH and corticosterone secretion in concert with AVP in nonstrained rats.
Centrally Administered Murine-Leptin Stimulates the Hypothalamus-Pituitary- Adrenal Axis through Arginine-Vasopressin
TLDR
Results suggest that intracerebroventricular leptin administration activates the HPA axis by AVP receptor activation through V1a receptors in the PVN which in turn activates CRH neurons to drive ACTH and corticosterone secretion in concert with AVP in nonstrained rats.
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TLDR
The major findings were that the spontaneous release of immunoreactive AVP from the dorsal hippocampus was episodic in nature and did not require the presence of bacitracin in the perfusion medium to reliably demonstrate its pattern of release.
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TLDR
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TLDR
The results indicate that AVP and related peptides affect passive avoidance behaviour by a direct central action and that the structural requirement for activation of central vasopressin receptors differs from that of the peripheral cardiovascular receptors, although both can be blocked by the same vasopressor antagonist.
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TLDR
3H‐AVP and 3H‐Antag showed similar labeling patterns when incubated with septal tissue slices, and Oxytocin was 100–1,000 fold less potent than AVP in competing for binding with both ligands.
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TLDR
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TLDR
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TLDR
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