Positive Darwinian selection after gene duplication in primate ribonuclease genes.

@article{Zhang1998PositiveDS,
  title={Positive Darwinian selection after gene duplication in primate ribonuclease genes.},
  author={J. X. Zhang and Helene F Rosenberg and Masatoshi Nei},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 7},
  pages={
          3708-13
        }
}
  • J. Zhang, H. Rosenberg, M. Nei
  • Published 1998
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Evolutionary mechanisms of origins of new gene function have been a subject of long-standing debate. Here we report a convincing case in which positive Darwinian selection operated at the molecular level during the evolution of novel function by gene duplication. The genes for eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) in primates belong to the ribonuclease gene family, and the ECP gene, whose product has an anti-pathogen function not displayed by EDN, was… Expand
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