Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel

@inproceedings{Wu2013PositionsO,
  title={Positions of β2 and β3 subunits in the large-conductance calcium- and voltage-activated BK potassium channel},
  author={Roland S. Wu and Guoxia Liu and Sergey I. Zakharov and Neelesh L Chudasama and Howard K. Motoike and A. Karlin and Steven O. Marx},
  booktitle={The Journal of general physiology},
  year={2013}
}
Large-conductance voltage- and Ca(2+)-gated K(+) channels are negative-feedback regulators of excitability in many cell types. They are complexes of α subunits and of one of four types of modulatory β subunits. These have intracellular N- and C-terminal tails and two transmembrane (TM) helices, TM1 and TM2, connected by an ∼100-residue extracellular loop. Based on endogenous disulfide formation between engineered cysteines (Cys), we found that in β2 and β3, as in β1 and β4, TM1 is closest to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.

Proceedings of the National Academy of Sciences of the United States of America • 2015

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels.

The Journal of biological chemistry • 2008
View 16 Excerpts
Highly Influenced

Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

Location of the beta 4 transmembrane helices in the BK potassium channel.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 7 Excerpts

Similar Papers

Loading similar papers…