Positions 94-98 of the lactose repressor N-subdomain monomer-monomer interface are critical for allosteric communication.


The central region of the LacI N-subdomain monomer-monomer interface includes residues K84, V94, V95, V96, S97, and M98. The side chains of these residues line the β-strands at this interface and interact to create a network of hydrophobic, charged, and polar interactions that significantly rearranges in different functional states of LacI. Prior work… (More)
DOI: 10.1021/bi101106x


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