Positionally selective growth of embryonic spinal cord neurites on muscle membranes.

  title={Positionally selective growth of embryonic spinal cord neurites on muscle membranes.},
  author={Hongyu Wang and Srinivas Rao Chadaram and Ann S Norton and R. M. Lewis and Jon Boyum and William R. Trumble and Joshua R Sanes and Michael B Laskowski},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={19 12},
Motor neurons from distinct positions along the rostrocaudal axis generally innervate muscles or muscle fibers from corresponding axial levels. These topographic maps of connectivity are partially restored after denervation or transplantation under conditions in which factors of timing and proximity are eliminated. It is therefore likely that motor neurons and some intramuscular structures bear cues that bias synapse formation in favor of positionally matched partners. To localize these cues… CONTINUE READING
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Overexpression of ephrin A5 disrupts neuromuscular topography

  • MB Laskowski, G Feng, M Nichol, JR Sanes
  • Soc Neurosci Abstr
  • 1998
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