Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)

@article{CastroGiner2009PositionallyCG,
  title={Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS)},
  author={Francesc Castro-Giner and Rafael de Cid and J. Ramos Gonz{\'a}lez and Deborah L. Jarvis and Joachim Heinrich and Christer Janson and Ernst Reidar Omenaas and Melanie C Matheson and Isabelle Pin and J. M. Antó and Matthias Wjst and Xavier Estivill and Manolis Kogevinas},
  journal={Thorax},
  year={2009},
  volume={65},
  pages={124 - 131}
}
Background Several genes identified by positional cloning have been associated with asthma and atopy, but few findings have been replicated. Age at onset of asthma has been associated with different phenotypic characteristics, and with variants at chromosome 17q21 identified through genome-wide association. This study examined the associations and age-specific effects on asthma, atopy and bronchial hyper-responsiveness (BHR) of five candidate genes previously identified by positional cloning… 
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