Positional cloning of the murine flavivirus resistance gene.

@article{Perelygin2002PositionalCO,
  title={Positional cloning of the murine flavivirus resistance gene.},
  author={Andrey A. Perelygin and Svetlana V. Scherbik and Igor B. Zhulin and Bronislava M Stockman and Yan A. Li and Margo A Brinton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 14},
  pages={9322-7}
}
Inbred mouse strains exhibit significant differences in their susceptibility to viruses in the genus Flavivirus, which includes human pathogens such as yellow fever, Dengue, and West Nile virus. A single gene, designated Flv, confers this differential susceptibility and was mapped previously to a region of mouse chromosome 5. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family. One 2'-5… CONTINUE READING

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