Positional cloning of the murine flavivirus resistance gene.

  title={Positional cloning of the murine flavivirus resistance gene.},
  author={Andrey A. Perelygin and Svetlana V. Scherbik and Igor B. Zhulin and Bronislava M Stockman and Yan A. Li and Margo A Brinton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 14},
Inbred mouse strains exhibit significant differences in their susceptibility to viruses in the genus Flavivirus, which includes human pathogens such as yellow fever, Dengue, and West Nile virus. A single gene, designated Flv, confers this differential susceptibility and was mapped previously to a region of mouse chromosome 5. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family. One 2'-5… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 99 extracted citations


Publications referenced by this paper.
Showing 1-3 of 3 references

Viral Pathogenesis, ed

  • M. A. Brinton
  • 1997

Molecular Cloning: A Laboratory Manual (Cold

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • 1989

Genetic Variants and Strains of the Laboratory Mice, ed

  • M. C. Green
  • 1981

Similar Papers

Loading similar papers…