• DOI:10.1038/372425A0
Corpus ID: 4359725

Positional cloning of the mouse obese gene and its human homologue

@article{Zhang1994PositionalCO,
  title={Positional cloning of the mouse obese gene and its human homologue},
  author={Y. Zhang and R. Proenca and M. Maffei and M. Barone and L. Leopold and J. Friedman},
  journal={Nature},
  year={1994},
  volume={372},
  pages={425-432}
}

Y. Zhang, R. Proenca, +3 authors J. Friedman

Published 1994

Biology, Medicine

Nature

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The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation ofobresults in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.