Positional cloning of the mouse obese gene and its human homologue

@article{Zhang1994PositionalCO,
  title={Positional cloning of the mouse obese gene and its human homologue},
  author={Y. Zhang and R. Proenca and M. Maffei and M. Barone and L. Leopold and J. Friedman},
  journal={Nature},
  year={1994},
  volume={372},
  pages={425-432}
}
  • Y. Zhang, R. Proenca, +3 authors J. Friedman
  • Published 1994
  • Biology, Medicine
  • Nature
  • The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation ofobresults in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot. 
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    References

    SHOWING 1-10 OF 39 REFERENCES
    Obesity genes: beneficial effects in heterozygous mice.
    • 114
    Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis.
    • G. Bray
    • Biology, Medicine
    • The Journal of nutrition
    • 1991
    • 227
    Molecular mapping of the mouse ob mutation.
    • 161
    The effects of lesions in the hypothalamus in parabiotic rats
    • G. E. Hervey
    • Chemistry, Medicine
    • The Journal of physiology
    • 1959
    • 426
    Molecular mapping of the mouse db mutation.
    • 88
    • PDF
    Food Intake as a Mechanism of Temperature Regulation *
    • J. Brobeck
    • Computer Science, Medicine
    • The Yale journal of biology and medicine
    • 1948
    • 326
    Tackling a weighty problem
    • 112
    Gene expression during liver regeneration.
    • 78
    REGULATION OF ENERGY INTAKE AND THE BODY WEIGHT: THE GLUCOSTATIC THEORY AND THE LIPOSTATIC HYPOTHESIS
    • J. Mayer
    • Medicine
    • Annals of the New York Academy of Sciences
    • 1955
    • 812
    Obesity: historical development of scientific and cultural ideas.
    • G. Bray
    • History, Medicine
    • International journal of obesity
    • 1990
    • 97