Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.

@article{Beutler2000PositionalCO,
  title={Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.},
  author={Bruce Beutler and Alexander N. Poltorak},
  journal={European cytokine network},
  year={2000},
  volume={11 2},
  pages={143-52}
}
In mice (and by inference, in all mammals), a single pathway exists to serve lipopolysaccharide (LPS) signal transduction, and as such, allelic mutations at a single locus entirely abolish responses to LPS in C3H/HeJ and C57BL/10ScCr mice. Positional cloning of this locus, known as Lps, revealed that mutations of the Toll-like receptor 4 gene (Tlr4) are responsible for endotoxin resistance. A quick succession of studies have shown Tlr4 to be the critical transmembrane component of the LPS… CONTINUE READING

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