Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.

@article{Libby2003PositionalCA,
  title={Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.},
  author={Brian J Libby and Laura G Reinholdt and John C. Schimenti},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 26},
  pages={15706-11}
}
The mouse meiotic mutant Mei1 was isolated in a screen for infertile mice descended from chemically mutagenized embryonic stem cells. Homozygotes of both sexes are sterile due to meiotic arrest caused by defects in chromosome synapsis. Notably, RAD51 protein does not load onto Mei1 mutant meiotic chromosomes, suggesting that there is a defect in either… CONTINUE READING