Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells.

@article{Hirose2001PositionWT,
  title={Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells.},
  author={Tetsuro Hirose and Joan A Steitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 23},
  pages={
          12914-9
        }
}
In mammalian cells, all small nucleolar RNAs (snoRNAs) that guide rRNA modification are encoded within the introns of host genes. A database analysis of human box C/D snoRNAs revealed conservation of their intronic location, with a preference for 70-80 nt upstream of the 3' splice site. Transfection experiments showed that synthesis of gas5-encoded U75 and U76 snoRNAs dropped significantly for mutant constructs possessing longer or shorter spacers between the snoRNA and the 3' splice site… CONTINUE READING

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