Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome.

Abstract

The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC) mutations by nonsense-mediated mRNA decay (NMD) is an important mechanism of long QT syndrome type 2 (LQT2). The mechanisms governing the recognition of PTC-containing hERG transcripts as NMD substrates have not been established. We… (More)
DOI: 10.1016/j.gene.2014.02.012

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@article{Gong2014PositionOP, title={Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome.}, author={Qiuming Gong and Matthew R. Stump and Zhengfeng Zhou}, journal={Gene}, year={2014}, volume={539 2}, pages={190-7} }