Position effects influence HIV latency reversal

@article{Chen2017PositionEI,
  title={Position effects influence HIV latency reversal},
  author={Heng-Chang Chen and Javier Pablo Martinez and Eduard Zorita and Andreas Meyerhans and Guillaume J. Filion},
  journal={Nature Structural &Molecular Biology},
  year={2017},
  volume={24},
  pages={47-54}
}
The main obstacle to curing HIV is the presence of latent proviruses in the bodies of infected patients. The partial success of reactivation therapies suggests that the genomic context of integrated proviruses can interfere with treatment. Here we developed a method called Barcoded HIV ensembles (B-HIVE) to map the chromosomal locations of thousands of individual proviruses while tracking their transcriptional activities in an infected cell population. B-HIVE revealed that, in Jurkat cells, the… CONTINUE READING
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