Position effect variegation at fission yeast centromeres.

@article{Allshire1994PositionEV,
  title={Position effect variegation at fission yeast centromeres.},
  author={Robin C. Allshire and Jean Paul Javerzat and Nicola J. Redhead and Gwen Cranston},
  journal={Cell},
  year={1994},
  volume={76 1},
  pages={157-69}
}
Chromatin structure at Schizosaccharomyces pombe centromeres is unusual. The insertion of the ura4 gene within these centromeres resulted in genetically identical cells mosaic for its expression. Placement of the ade6 gene within cen1 or cen3 resulted in red-white sectored colonies, demonstrating the instability of gene expression. The occurrence of pink colonies implied that intermediate levels of repression were established. Repression of both genes within centromeres was temperature… CONTINUE READING

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