Position-dependent plasticity of distinct progenitor types in the primitive streak

  title={Position-dependent plasticity of distinct progenitor types in the primitive streak},
  author={Filip J. Wymeersch and Yali Huang and Guillaume Blin and Noem{\'i} Cambray and Ron Wilkie and Frederick K. Wong and Valerie Wilson},
The rostrocaudal (head-to-tail) axis is supplied by populations of progenitors at the caudal end of the embryo. Despite recent advances characterising one of these populations, the neuromesodermal progenitors, their nature and relationship to other populations remains unclear. Here we show that neuromesodermal progenitors are a single Sox2(low)T(low) entity whose choice of neural or mesodermal fate is dictated by their position in the progenitor region. The choice of mesoderm fate is Wnt… CONTINUE READING
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