Position and orientation of the globular domain of linker histone H5 on the nucleosome

@article{Zhou1998PositionAO,
  title={Position and orientation of the globular domain of linker histone H5 on the nucleosome},
  author={Yb Zhou and Sue Ellen Gerchman and Venki Ramakrishnan and Andrew Travers and Serge Muyldermans},
  journal={Nature},
  year={1998},
  volume={395},
  pages={402-405}
}
  • Yb Zhou, Sue Ellen Gerchman, +2 authors Serge Muyldermans
  • Published 1998
  • Biology, Medicine
  • Nature
  • It is essential to identify the exact location of the linker histone within nucleosomes, the fundamental packing units of chromatin, in order to understand how condensed, transcriptionally inactive chromatin forms. Here, using a site-specific protein–DNA photo-crosslinking method, we map the binding site and the orientation of the globular domain of linker histone H5 on mixed-sequence chicken nucleosomes. We show, in contrast to an earlier model, that the globular domain forms a bridge between… CONTINUE READING

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