Position and orientation of gallated proanthocyanidins in lipid bilayer membranes: influence of polymerization degree and linkage type.

@article{Zhu2018PositionAO,
  title={Position and orientation of gallated proanthocyanidins in lipid bilayer membranes: influence of polymerization degree and linkage type.},
  author={Wei Zhu and Ibrahim Khalifa and Jinming Peng and Chunmei Li},
  journal={Journal of biomolecular structure & dynamics},
  year={2018},
  volume={36 11},
  pages={
          2862-2875
        }
}
It is well known that the biological activity of gallated proanthocyanidins (PAs) is highly structure-dependent. Polymerization degree (DP) and linkage types affect their biological activity greatly. Positions and orientations of gallated PAs in lipid bilayer reveal their structure-function activity at the molecular level. The present work aimed at determining the locations and orientations of epigallocatechin-3-gallate (EGCG) and its derivatives: A-type and B-type EGCG dimers and trimers in 1… CONTINUE READING