Position Paper: Cathartics

@article{Toxicologists2004PositionPC,
  title={Position Paper: Cathartics},
  author={Clinical Toxicologists},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2004},
  volume={42},
  pages={243 - 253}
}
The administration of a cathartic alone has no role in the management of the poisoned patient and is not recommended as a method of gut decontamination. Experimental data are conflicting regarding the use of cathartics in combination with activated charcoal. No clinical studies have been published to investigate the ability of a cathartic, with or without activated charcoal, to reduce the bioavailability of drugs or to improve the outcome of poisoned patients. Based on available data, the… 
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References

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TLDR
The results of this experimental study indicate that Na2SO4 reduces the gastrointestinal absorption of aspirin, but not that of pentobarbital, chlorpheniramine, or chloroquine; and saline cathartics should not be used in lieu of AC for treatment of poison ingestions.
Hypermagnesemia. A potential complication during treatment of theophylline intoxication with oral activated charcoal and magnesium-containing cathartics.
TLDR
It is suggested that sorbitol be considered the cathartic agent of choice in the treatment of theophylline toxicity with OAC and magnesium citrate.
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TLDR
Sorbitol, when administered with activated charcoal in the treatment of children with acute ingestions, produced a shorter time to first stool and more stools than magnesium citrate, magnesium sulfate, or water.
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TLDR
Though a prospective, controlled study needs to be performed, variation in dosage of the CSS may be appropriate in select patient groups to offset the effects of the ingestant on bowel motility.
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TLDR
The effects of saline cathartics on the gastrointestinal transit time of activated charcoal were investigated in six healthy volunteers and some volunteers complained of slight abdominal discomfort in all the phases except the Andrew's Liver Salt phase.
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TLDR
Cathartic efficiency is enhanced by alteration of gastrointestinal motility with propantheline, which reduces the transit and residence times of activated charcoal.
Effects of Magnesium Citrate and Clidinium Bromide on the Excretion of Activated Charcoal in Normal Subjects
TLDR
The results support previous studies of the effects of cathartics on the excretion of activated charcoal, and suggest that cathartic efficacy is not inhibited by anticholinergic drugs when used in therapeutic doses.
Contribution of sorbitol combined with activated charcoal in prevention of salicylate absorption.
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