Portraying breast cancers with long noncoding RNAs

@inproceedings{Grembergen2016PortrayingBC,
  title={Portraying breast cancers with long noncoding RNAs},
  author={Olivier Van Grembergen and Martin Bizet and Eric J de Bony and Emilie Calonne and Pascale Putmans and Sylvain Broh{\'e}e and Catharina Olsen and M Q Guo and Gianluca Bontempi and Christos P. Sotiriou and Matthieu Defrance and François Fuks},
  booktitle={Science Advances},
  year={2016}
}
Evidence is emerging that long noncoding RNAs (lncRNAs) may play a role in cancer development, but this role is not yet clear. We performed a genome-wide transcriptional survey to explore the lncRNA landscape across 995 breast tissue samples. We identified 215 lncRNAs whose genes are aberrantly expressed in breast tumors, as compared to normal samples. Unsupervised hierarchical clustering of breast tumors on the basis of their lncRNAs revealed four breast cancer subgroups that correlate tightly… CONTINUE READING

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