Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome

@article{Ribero2007PortalVE,
  title={Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome},
  author={Dario Ribero and Eddie K. Abdalla and David C. Madoff and Matteo Donadon and Evelyne M. Loyer and Jean-Nicolas Vauthey},
  journal={British Journal of Surgery},
  year={2007},
  volume={94}
}
This study evaluated the safety of portal vein embolization (PVE), its impact on future liver remnant (FLR) volume and regeneration, and subsequent effects on outcome after liver resection. 
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406 Citations
Highly Influential Citations
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Background Citations
89
Methods Citations
26
Results Citations
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406 Citations

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Citation Type

Liver regeneration following repeated reversible portal vein embolization in an experimental model
TLDR
The aim of this study was to assess the effect of repeated reversible PVE on hepatocyte proliferation and subsequent liver hypertrophy in rodents.
Portal vein embolization (prior to major hepatectomy) effects on regeneration, resectability, and outcome
  • E. Abdalla
  • Medicine
    Journal of surgical oncology
  • 2010
TLDR
Oncologic outcomes following resection in patients with appropriately applied PVE are excellent and Absolute volume and volume change of the FLR after PVE (interpreted in context of liver disease) predict adequate liver function postresection.
Radiological aspects of portal vein embolization
TLDR
The role of dynamic liver function tests and CT-volumetry in risk assessment before major liver resection is evaluated in several clinical studies.
Portal vein embolization prior to major liver resection
TLDR
The aim was to describe the experience of PVE for patients with large or multifocal malignant liver tumours who initially were deemed unresectable.
Surgical resection of primary and metastatic hepatic malignancies following portal vein embolization
TLDR
The initial experience with PVE is reported, and potential predictors of unresectability following PVE are identified and identified.
Right portal vein embolization with absolute ethanol in major hepatic resection for hepatobiliary malignancy
This study aimed to evaluate the safety and efficacy of preoperative right portal vein embolization (PVE) with absolute ethanol in patients with hepatobiliary malignancies.
Preoperative portal vein embolization (PVE) for patients with hepatocellular carcinoma can improve resectability and may improve disease‐free survival
The aim of this study is to identify the efficacy of portal vein embolization (PVE) before right hepatectomy in patients with hepatocellular carcinoma (HCC) with regard to hepatic function, surgical…
Impact of portal vein embolization on long‐term survival of patients with primarily unresectable colorectal liver metastases
TLDR
This study evaluated long‐term survival in patients with CLM who underwent hepatectomy following PVE, finding that PVE increases the resectability of initially unresectable colorectal liver metastases.
Portal vein embolization improves rate of resection of extensive colorectal liver metastases without worsening survival
Most patients requiring an extended right hepatectomy (ERH) have an inadequate standardized future liver remnant (sFLR) and need preoperative portal vein embolization (PVE). However, the clinical and…
Portal vein embolization and its effect on tumour progression for colorectal cancer liver metastases
The aim of this study was to evaluate the long‐term outcomes of patients with colorectal cancer liver metastasis (CRCLM) exhibiting disease progression after portal vein embolization (PVE).
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References

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TLDR
Portal vein embolization was proposed to induce hypertrophy of the anticipated liver remnant in order to reduce complications from inadequate postresection hepatic size and function.
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The aim of this study was to evaluate serial changes in liver volume after major hepatectomy for biliary cancer and to elucidate clinical factors influencing liver regeneration.
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During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma
TLDR
The aim of this study was to determine in humans the growth rate of liver parenchyma during regeneration and the growth rates of liver metastases during the same process.
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TLDR
Although exclusively applicable in a limited subset of patients, POPE widens the possibilities of curative hepatectomies, because it induces sound hypertrophy of unembolized liver segments, and Cyanoacrylate seems to ensure better and fasterhypertrophy.
Portal Vein Embolization Before Right Hepatectomy: Prospective Clinical Trial
TLDR
Before elective right hepatectomy, the hypertrophy of FLR induced by PVE had no beneficial effect on the postoperative course in patients with normal liver, and before chronic liver disease, PVE significantly decreased the incidence of postoperative complications as well as the intensive care unit stay and total hospital stay.
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TLDR
The increase in the transforming growth factor-alpha level 14 days after portal vein embolization was the only independent factor related to the hypertrophy of the nonembolized liver and may be a useful indicator in the scheduling of subsequent extensive hepatectomies.
Proliferative activity of intrahepatic colorectal metastases after preoperative hemihepatic portal vein embolization
TLDR
It is concluded that PVE increases tumor growth and probably is associated with enhanced recurrence of disease and patient selection for PVE should be cautious.
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