Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein.

@article{Mithieux2005PortalSO,
  title={Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein.},
  author={Gilles Mithieux and Pierre Misery and Christophe Magnan and Bruno Pillot and Amandine Gautier-Stein and Christine Bernard and Fabienne Rajas and Carine Zitoun},
  journal={Cell metabolism},
  year={2005},
  volume={2 5},
  pages={
          321-9
        }
}
Protein feeding is known to decrease hunger and subsequent food intake in animals and humans. It has also been suggested that glucose appearance into portal vein, as occurring during meal assimilation, may induce comparable effects. Here, we connect these previous observations by reporting that intestinal gluconeogenesis (i.e., de novo synthesis of glucose) is induced during the postabsorptive time (following food digestion) in rats specifically fed on protein-enriched diet. This results in… CONTINUE READING
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