Portal or subcutaneous insulin infusion: efficacy and impact on liver inflammation.

@article{Dal2015PortalOS,
  title={Portal or subcutaneous insulin infusion: efficacy and impact on liver inflammation.},
  author={St{\'e}phanie Dal and Nathalie Jeandidier and Ana{\"i}s Schaschkow and Anne-H{\'e}l{\`e}ne Spizzo and Elodie Seyfritz and Cynthia Sookhareea and William Bietiger and Claude P{\'e}ronet and François Moreau and Michel Pinget and E Maillard and S{\'e}verine Sigrist},
  journal={Fundamental & clinical pharmacology},
  year={2015},
  volume={29 5},
  pages={488-98}
}
Intraperitoneal insulin allows physiological portal insulin administration and first-pass hepatic insulin extraction, but the impact on liver metabolism and inflammation is unknown. Our objective was to compare the impact, on metabolic control and liver function, of the same dose of insulin administered either intraperitoneally or subcutaneously during continuous infusion in diabetic rats. Wistar rats were randomly divided into 4 groups: control (C), untreated diabetic (streptozotocin, 100 mg… CONTINUE READING