Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles.

@article{Lemoinne2015PortalMP,
  title={Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles.},
  author={Sara Lemoinne and Axelle Cadoret and Pierre-Emmanuel Rautou and Haquima El Mourabit and Vlad Ratziu and Christophe Corpechot and Christian Rey and Nelly Bosselut and V{\'e}ronique Barbu and Dominique Wendum and G{\'e}rard Feldmann and Christelle Boulanger and Corneliu H{\'e}n{\'e}gar and Chantal Housset and Dominique Thabut},
  journal={Hepatology},
  year={2015},
  volume={61 3},
  pages={
          1041-55
        }
}
UNLABELLED Liver fibrosis expanding from portal tracts and vascular remodeling are determinant factors in the progression of liver diseases to cirrhosis. In the present study, we examined the potential contribution of portal myofibroblasts (PMFs) to the vascular changes leading to cirrhosis. The analyses of liver cells based on the transcriptome of rat PMFs, compared to hepatic stellate cell HSC-derived myofibroblasts in culture, identified collagen, type XV, alpha 1 (COL15A1) as a marker of… CONTINUE READING
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