Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal.

@article{Zheng2010PortalGI,
  title={Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal.},
  author={Dan Zheng and Viorica Ionut and Vahe Mooradian and Darko Stefanovski and Richard N Bergman},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 2},
  pages={E346-53}
}
The full impact of the liver, through both glucose production and uptake, on systemic glucose appearance cannot be readily studied in a classical glucose clamp because hepatic glucose metabolism is regulated not only by portal insulin and glucose levels but also portal glucose delivery (the portal signal). In the present study, we modified the classical… CONTINUE READING