Portal endotoxemia stimulates the release of an immunosuppressive factor from alveolar and splenic macrophages.


Impairment of cell-mediated immunity is both a common manifestation of critical illness and a potential cause of increased infectious morbidity and mortality. The mechanisms responsible for alterations in systemic immune regulation are incompletely understood; however, monocytes and fixed tissue macrophages appear to play a central role. We have previously… (More)